Traditional process support systems typically offer a static composition of atomic tasks to more powerful services. In the real world, however, processes change over time: business needs are rapidly evolving thus changing the work itself and relevant information may be unknown until workflow execution run-time. Hence, the static approach does not sufficiently address the need for dynamism. Based on applications in the life science domain this paper puts forward five requirements for dynamic process support systems. These demand a focus on a tight user interaction in the whole process life cycle. The system and the user establish a continuous feedback loop resulting in a mixed-initiative approach requiring a partial execution and resumption feature to adapt a running process to changing needs. Here we present our prototype implementation NExT and discuss a preliminary validation based on a real-world scenario. 1 An Illustrating Scenario - As is Peter, the chemist in our scenario, nee...