Can We Trust the Transgenic Mouse? Insights from Computer Simulations

Abstract. Over the past several decades, the mouse has gained prominence in the cardiac electrophysiology literature as the animal model of choice. Using computer models of the mouse and human ECG, this paper is a step toward understanding when the mouse succeeds and fails to mimic functional changes resulting from disease states and drug interactions.

• Type: Conference
• Year: 2007
• Where: FIMH
• Authors: Joseph Tranquillo, Adhira Sunkara
• Keywords: Cardiac Electrophysiology Literature, FIMH 2007, Mimic Functional Changes, Mouse