Requirements volatility is an issue in software development life cycle which often originated from our incomplete knowledge about the domain of interest. In this paper, we propose an agent-based approach to manage evolving requirements in biomedical software applications using an integrated ontology-driven framework. Categories and Subject Descriptors K.6.3 [Management of Computing and Information Systems]: Software Management – Software Maintenance. General Terms Management, Design, Standardization. Keywords Software Requirement; Change management; Ontology; Agent