Haplotype Inference Via Hierarchical Genotype Parsing

The within-species genetic variation due to recombinations leads to a mosaic-like structure of DNA. This structure can be modeled, e.g. by parsing sample sequences of current DNA with respect to a small number of founders. The founders represent the ancestral sequence material from which the sample was created in a sequence of recombination steps. This scenario has recently been successfully applied on developing probabilistic Hidden Markov Methods for haplotyping genotypic data. In this paper we introduce a combinatorial method for haplotyping that is based on a similar parsing idea. We formulate a polynomial-time parsing algorithm that finds minimum cross-over parse in a simplified ‘flat’ parsing model that ignores the historical hierarchy of recombinations. The problem of constructing optimal founders that would give minimum possible parse for given genotypic sequences is shown NP-hard. A heuristic locally-optimal algorithm is given for founder construction. Combined with fl...

• Type: Conference
• Year: 2007
• Where: WABI
• Authors: Pasi Rastas, Esko Ukkonen
• Keywords: Algorithms, Parsing, Polynomial-time Parsing Algorithm, Similar Parsing Idea, WABI 2007