Aldose Reductase and Nitric Oxide Synthase Role in Diabetic Retinopathy: A Bioinformatics Study

- Diabetic retinopathy is the leading cause of blindness among patients with diabetes mellitus. We investigated the role of several proteins that are likely to be involved in the diabetic retinopathy by employing multiple sequence alignment using ClustalW tool and constructed a phylogram tree using functional protein sequences extracted from NCBI. Phylogram was constructed using Neighbor-Joining Algorithm in Bioinformatics approach. Phylogram showed that Aldose Reductase and Nitric oxide Synthase are closely associated with diabetic retinopathy. Based on the results of the present study, it is suggested that Aldose Reductase and Nitric oxide Synthase play a significant role in the pathogenesis of diabetic retinopathy. It is likely that other proteins such as VEGF (Vascular Endothelial Growth Factor) that also play a role in diabetic retinopathy do so by modulating the activities of Aldose Reductase and Nitric oxide Synthase.

• Type: Conference
• Year: 2007
• Where: BIOCOMP
• Authors: Hanuman Thota, Nageswara rao Kunjam, Suresh Babu Changalasetty, Allam Appa Rao, Ramachandra Sridhar Gumpeny, Undurti N. Das, Reddi Kirankumar, T. K. Rama Krishna Rao
• Keywords: Aldose Reductase, BIOCOMP 2007, Bioinformatics, Diabetic Retinopathy, Nitric Oxide Synthase