Algorithms to Distinguish the Role of Gene-Conversion from Single-Crossover Recombination in the Derivation of SNP Sequences in

Meiotic recombination is a fundamental biological event and one of the principal evolutionary forces responsible for shaping genetic variation within species. In addition to its fundamental role, recombination is central to several critical applied problems. The most important example is "association mapping" in populations, which is widely hoped to help find genes that influence genetic diseases [3, 4]. Hence, a great deal of recent attention has focused on problems of inferring the historical derivation of sequences in populations when both mutations and recombinations have occurred. In the algorithms literature, most of that recent work has been directed to single-crossover recombination. However, gene-conversion is an important, and more common, form of (two-crossover) recombination which has been much less investigated in the algorithms literature. In this paper we explicitly incorporate gene-conversion into discrete methods to study historical recombination. We are conc...

• Type: Conference
• Year: 2006
• Where: RECOMB
• Authors: Yun S. Song, Zhihong Ding, Dan Gusfield, Charles H. Langley, Yufeng Wu
• Keywords: Computational Biology, Effective Upper Bounds, Fundamental Biological Event, Principal Evolutionary Forces, RECOMB 2006