Artificial neural network approach for selection of susceptible single nucleotide polymorphisms and construction of prediction m

Background: Screening of various gene markers such as single nucleotide polymorphism (SNP) and correlation between these markers and development of multifactorial disease have previously been studied. Here, we propose a susceptible marker-selectable artificial neural network (ANN) for predicting development of allergic disease. Results: To predict development of childhood allergic asthma (CAA) and select susceptible SNPs, we used an ANN with a parameter decreasing method (PDM) to analyze 25 SNPs of 17 genes in 344 Japanese people, and select 10 susceptible SNPs of CAA. The accuracy of the ANN model with 10 SNPs was 97.7% for learning data and 74.4% for evaluation data. Important combinations were determined by effective combination value (ECV) defined in the present paper. Effective 2-SNP or 3-SNP combinations were found to be concentrated among the 10 selected SNPs. Conclusion: ANN can reliably select SNP combinations that are associated with CAA. Thus, the ANN can be used to charact...

• Type: Journal
• Year: 2004
• Where: BMCBI
• Authors: Yasuyuki Tomita, Shuta Tomida, Yuko Hasegawa, Yoichi Suzuki, Taro Shirakawa, Takeshi Kobayashi, Hiroyuki Honda
• Keywords: Allergic Asthma, BMCBI 2004, SNPs, Susceptible Snps