BMCBI
2004
13 years 11 months ago
2004
Background: The genomes of an increasing number of species are being investigated through generation of expressed sequence tags (ESTs). However, ESTs are prone to sequencing error...
BMCBI
2004
13 years 11 months ago
2004
Background: An important challenge for transcript counting methods such as Serial Analysis of Gene Expression (SAGE), "Digital Northern" or Massively Parallel Signature ...
BMCBI
2004
13 years 11 months ago
2004
Background: To identify differentially expressed genes, it is standard practice to test a twosample hypothesis for each gene with a proper adjustment for multiple testing. Such te...
BMCBI
2004
13 years 11 months ago
2004
Background: The behaviors of cells in metazoans are context dependent, thus large-scale multicellular modeling is often necessary, for which cellular automata are natural candidat...
BMCBI
2004
13 years 11 months ago
2004
Background: Once specific genes are identified through high throughput genomics technologies there is a need to sort the final gene list to a manageable size for validation studie...
BMCBI
2004
13 years 11 months ago
2004
Background: Identifying all protein-protein interactions in an organism is a major objective of proteomics. A related goal is to know which protein pairs are present in the same p...
BMCBI
2004
13 years 11 months ago
2004
Background: In population-based studies, it is generally recognized that single nucleotide polymorphism (SNP) markers are not independent. Rather, they are carried by haplotypes, ...
BMCBI
2004
13 years 11 months ago
2004
Background: Microarray and other high-throughput technologies are producing large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed...
BMCBI
2004
13 years 11 months ago
2004
Background: In the microarray experiment, many undesirable systematic variations are commonly observed. Normalization is the process of removing such variation that affects the me...
BMCBI
2004
13 years 11 months ago
2004
Background: cDNA microarrays are a powerful means to screen for biologically relevant gene expression changes, but are often limited by their ability to detect small changes accur...