- Serious games can help in training medical first responders by providing emergency simulations which are always available, safer and possibly cheaper than real-world simulations. However, serious games for training emergency medical services (EMS) nurses must take into account the familiarity of the users with 3D videogames, which could be very low. In this paper, we present a prototype of the serious game we are developing for training EMS nurses in decision making and the results of a user study we have carried out with its intended users. The main purposes of the study were to assess nurses’ acceptance of this kind of application, as well as to collect suggestions and requirements from nurses.