BLISS: biding site level identification of shared signal-modules in DNA regulatory sequences

Background: Regulatory modules are segments of the DNA that control particular aspects of gene expression. Their identification is therefore of great importance to the field of molecular genetics. Each module is composed of a distinct set of binding sites for specific transcription factors. Since experimental identification of regulatory modules is an arduous process, accurate computational techniques that supplement this process can be very beneficial. Functional modules are under selective pressure to be evolutionarily conserved. Most current approaches therefore attempt to detect conserved regulatory modules through similarity comparisons at the DNA sequence level. However, some regulatory modules, despite the conservation of their responsible binding sites, are embedded in sequences that have little overall similarity. Results: In this study, we present a novel approach that detects conserved regulatory modules via comparisons at the binding site level. The technique compares the ...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Hailong Meng, Arunava Banerjee, Lei Zhou
• Keywords: Binding Site, BMCBI 2006, Little Overall Similarity, Regulatory Modules