CDD: a Conserved Domain Database for the functional annotation of proteins

NCBI’s Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints. CDD includes manually curated domain models that make use of protein 3D structure to refine domain models and provide insights into sequence/ structure/function relationships. Manually curated models are organized hierarchically if they describe domain families that are clearly related by common descent. As CDD also imports domain family models from a variety of external sources, it is a partially redundant collection. To simplify protein annotation, redundant models and models describing homologous families are clustered into superfamilies. By default, domain footprints are annotated with the corresponding superfamily designation, on top of which specific annotation may indicate high-confidence assignment of family membership. Pre-computed domain annotation is available for proteins in the...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Aron Marchler-Bauer, Shennan Lu, John B. Anderson, Farideh Chitsaz, Myra K. Derbyshire, Carol DeWeese-Scott, Jessica H. Fong, Lewis Y. Geer, Renata C. Geer, Noreen R. Gonzales, Marc Gwadz, David I. Hurwitz, John D. Jackson, Zhaoxi Ke, Christopher J. Lanczycki, Fu Lu, Gabriele H. Marchler, Mikhail Mullokandov, Marina V. Omelchenko, Cynthia L. Robertson, James S. Song, Narmada Thanki, Roxanne A. Yamashita, Dachuan Zhang, Naigong Zhang, Chanjuan Zheng, Stephen H. Bryant
• Keywords: NAR 2011, Protein 3D Structure, Protein Sequences, Redundant Collection