Hospitals have been challenged in recent years to deliver high quality care with limited resources. Given the pressure to contain costs, developing procedures for optimal resource allocation becomes more and more critical in this context. Indeed, under/overutilization of emergency room and ward resources can either compromise a hospital’s ability to provide the best possible care, or result in precious funding going toward underutilized resources. Simulation-based optimization tools then help facilitating the planning and management of hospital services, by maximizing/minimizing some specific indices (e.g. net profit) subject to given clinical and economical constraints. In this work, we develop a simulation-based optimization approach for the B Massimo Roma