The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microa

Background: The Tissue Microarray (TMA) facilitates high-throughput analysis of hundreds of tissue specimens simultaneously. However, bottlenecks in the storage and manipulation of the data generated from TMA reviews have become apparent. A number of software applications have been developed to assist in image and data management; however no solution currently facilitates the easy online review, scoring and subsequent storage of images and data associated with TMA experimentation. Results: This paper describes the design, development and validation of the Virtual Tissue Matrix (VTM). Through an intuitive HTML driven user interface, the VTM provides digital/virtual slide based images of each TMA core and a means to record observations on each TMA spot. Data generated from a TMA review is stored in an associated relational database, which facilitates the use of flexible scoring forms. The system allows multiple users to record their interpretation of each TMA spot for any parameters ass...

• Type: Journal
• Year: 2006
• Where: BMCBI
• Authors: Catherine M. Conway, Deirdre O'Shea, Sallyann O'Brien, Darragh K. Lawler, Graham D. Dodrill, Anthony O'Grady, Helen Barrett, Christian Gulmann, Lorraine O'Driscoll, William M. Gallagher, Elaine W. Kay, Daniel G. O'Shea
• Keywords: BMCBI 2006, Images, Reviews, TMA Spot