Evaluation of GO-based functional similarity measures using S. cerevisiae protein interaction and expression profile data

Background: Researchers interested in analysing the expression patterns of functionally related genes usually hope to improve the accuracy of their results beyond the boundaries of currently available experimental data. Gene ontology (GO) data provides a novel way to measure the functional relationship between gene products. Many approaches have been reported for calculating the similarities between two GO terms, known as semantic similarities. However, biologists are more interested in the relationship between gene products than in the scores linking the GO terms. To highlight the relationships among genes, recent studies have focused on functional similarities. Results: In this study, we evaluated five functional similarity methods using both protein-protein interaction (PPI) and expression data of S. cerevisiae. The receiver operating characteristics (ROC) and correlation coefficient analysis of these methods showed that the maximum method outperformed the other methods. Statistica...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Tao Xu, LinFang Du, Yan Zhou
• Keywords: BMCBI 2008, Gene Products, GO Terms, Related Genes