In this paper, we present the Daedalus framework, which allows for traversing the path from sequential application specification to a working MP-SoC prototype in FPGA technology with the (parallelized) application mapped onto it in only a matter of hours. During this traversal, which offers a high degree of automation, guidance is provided by Daedalus’ integrated system-level design space exploration environment. We show that Daedalus offers remarkable potentials for quickly experimenting with different MP-SoC architectures and exploring system-level design options during the very early stages of design. Using a case study with a Motion-JPEG encoder application, we illustrate Daedalus’ design steps and demonstrate its efficiency. Categories and Subject Descriptors J.6 [Computer-aided Engineering]: Computer-aided design General Terms Performance, design Keywords Design space exploration, system-level design and synthesis, rapid prototyping