Human-Centered Computing (HCC) is a set of methodologies that apply to any field that uses computers, in any form, in applications in which humans directly interact with devices or systems that use computer technologies. In this paper, we give an overview of HCC from a Multimedia perspective. We describe what we consider to be the three main areas of Human-Centered Multimedia (HCM): media production, analysis, and interaction. In addition, we identify the core characteristics of HCM, describe example applications, and propose a research agenda for HCM. Categories and Subject Descriptors I.4.9 [Image Processing and Computer Vision]: Applications; H.5.2 [User Interfaces]: User-centered Design General Terms Algorithms, Measurement, Human Factors. Keywords Human-Centered Computing, Multimedia, Multimodal Interaction, Human-Computer Interfaces.