Inference of Chromosome-Specific Copy Numbers Using Population Haplotypes

Background: Using microarray and sequencing platforms, a large number of copy number variations (CNVs) have been identified in humans. In practice, because our human genome is a diploid, these platforms are limited to or more accurate for detecting total copy numbers rather than chromosome-specific copy numbers at each of the two homologous chromosomes. Nevertheless, the analysis of linkage disequilibrium (LD) between CNVs and SNPs indicates that distinct copy numbers often sit on their own background haplotypes. Results: We propose new computational models for inferring chromosome-specific copy numbers by distinguishing background haplotypes of each copy number. The formulated problems are shown to be NP-hard and approximation/heuristic algorithms are developed. Simulation indicates that our method is accurate and outperforms the existing approach. By testing the program in 60 parent-offspring trios, the inferred chromosomespecific copy numbers are highly consistent with the law of M...

• Type: Journal
• Year: 2011
• Where: BMCBI
• Authors: Yao-Ting Huang, Min-Han Wu
• Keywords: Biometrics, BMCBI 2011, Disease Susceptibility, DNA Segment, Nucleotide Polymorphisms