Inferring modules of functionally interacting proteins using the Bond Energy Algorithm

Background: Non-homology based methods such as phylogenetic profiles are effective for predicting functional relationships between proteins with no considerable sequence or structure similarity. Those methods rely heavily on traditional similarity metrics defined on pairs of phylogenetic patterns. Proteins do not exclusively interact in pairs as the final biological function of a protein in the cellular context is often hold by a group of proteins. In order to accurately infer modules of functionally interacting proteins, the consideration of not only direct but also indirect relationships is required. In this paper, we used the Bond Energy Algorithm (BEA) to predict functionally related groups of proteins. With BEA we create clusters of phylogenetic profiles based on the associations of the surrounding elements of the analyzed data using a metric that considers linked relationships among elements in the data set. Results: Using phylogenetic profiles obtained from the Cluster of Ortho...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Ryosuke Watanabe, Enrique Morett, Edgar E. Vallejo
• Keywords: BMCBI 2008, Functional Relationships, Phylogenetic Profiles, Proteins