— Humans can control MIMO (Multiple-Input Multiple-Output) objects appropriately using knowledge of the MIMO object, which can be referred to as human MIMO control knowledge. An example of a MIMO object is a twowheeled vehicle. A skilled operator is able to operate a twowheeled vehicle cleverly using human knowledge. In this paper, an intelligent MIMO control (iMIMOc) method that can be built using MIMO knowledge is proposed. Furthermore, the iMIMOc method is applied to a two-wheeled vehicle, and the effectiveness is confirmed. The simulation results show the validity of this control method.