The Mathematical Model of Subtractive Hybridization and Its Practical Application

A novel theory of subtractive hybridization including (or based on) the kinetic model of this process was proposed. A computer program modeling the process of subtraction wasdeveloped. Basing on the theory, a novel method of subtractive hybridization was proposed allowing routine comparison of genomes and products of genome expression. Themethodwasapplied to studies of the genetic mechanismsof embryogenesis, regeneration, cell differentiation and tumortransformation.

• Type: Conference
• Year: 1996
• Where: ISMB
• Authors: Olga D. Ermolaeva, Sergey A. Lukyanov, Eugene D. Sverdlov
• Keywords: Computational Biology, Genetic Mechanismsof Embryogenesis, ISMB 1996, Kinetic Model, Subtractive Hybridization