Numerous studies have shown that Operating System (OS) noise is one of the reasons for significant performance degradation in clustered architectures. Although many studies examine the OS noise for High Performance Computing (HPC), especially in multi-processor/core systems, most of them focus on 2- or 4-core systems. In this paper, we analyze the major sources of OS noise on a massive multithreading processor, the Sun UltraSPARC T1, running Linux and Solaris. Since a real system is too complex to analyze, we compare those results with a low-overhead runtime environment: the Netra Data Plane Software Suite (Netra DPS). Our results show that the overhead introduced by the OS timer interrupt in Linux and Solaris depends on the particular core and hardware context in which the application is running. This overhead is up to 30% when the application is executed on the same hardware context of the timer interrupt handler and up to 10% when the application and the timer interrupt handler ru...