A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools

Background: This paper describes a microarray study including data quality control, data analysis and the analysis of the mechanism of toxicity (MOT) induced by 1-methyl-4-phenylpyridinium (MPP+) in a rat adrenal pheochromocytoma cell line (PC12 cells) using bioinformatics tools. MPP+ depletes dopamine content and elicits cell death in PC12 cells. However, the mechanism of MPP+induced neurotoxicity is still unclear. Results: In this study, Agilent rat oligo 22K microarrays were used to examine alterations in gene expression of PC12 cells after 500

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Zengjun Xu, Tucker A. Patterson, Jonathan D. Wren, Tao Han, Leming M. Shi, Helen Duhart, Syed F. Ali, William Slikker Jr.
• Keywords: BMCBI 2005, Gene Expression, MPP+ Treatment, PC12 Cells