Mining and Predicting CpG islands

— A DNA sequence can be described as a string composed of four symbols: A, T, C and G. Each symbol represents a chemically distinct nucleotide molecule. Combinations of two nucleotides are called dinucleotides and CpG islands represent regions of a DNA sequence, certain substrings, which are enriched in CpG dinucleotides (C followed by G). CpG islands represent a prominent and enigmatic feature of vertebrate genomes. They are associated with the promoters of more than 60% of all human genes and represent a critical target for transcriptional control. Methylation of these CpG islands leads to structural changes in the DNA that stops the expression of any associated gene (genesilencing). The factors that provoke or impede methylation are currently all but unknown. In general, the maintenance of a particular pattern of methylated CpG dinucleotides represents a critical regulatory system during a host of normal developmental processes, but the erroneous methylation of CpG islands and the...

• Type: Conference
• Year: 2007
• Where: FUZZIEEE
• Authors: Christopher Previti, Oscar Harari, Coral del Val
• Keywords: Artificial Intelligence, CpG Dinucleotides, CpG Islands, DNA Sequence, FUZZIEEE 2007