Multi-scale modelling in computational biomedicine

The inherent complexity of biomedical systems is well recognized; they are multi-scale, multi-science systems, bridging a wide range of temporal and spatial scales. This article reviews the currently emerging field of multi-scale modelling in computational biomedicine. Many exciting multi-scale models exist or are under development. However, an underpinning multi-scale modelling methodology seems to be missing. We propose a direction that complements the classic dynamical systems approach and introduce two distinct case studies, transmission of resistance in human immunodeficiency virus spreading and in-stent restenosis in coronary artery disease.

• Type: Journal
• Year: 2010
• Where: BIB
• Authors: Peter M. A. Sloot, Alfons G. Hoekstra
• Keywords: BIB 2010, Classic Dynamical Systems, Exciting Multi-scale Models, Underpinning Multi-scale Modelling