MutationAligner: a resource of recurrent mutation hotspots in protein domains in cancer

The MutationAligner web resource, available at http:// www.mutationaligner.org, enables discovery and exploration of somatic mutation hotspots identified in protein domains in currently (mid-2015) more than 5000 cancer patient samples across 22 different tumor types. Using multiple sequence alignments of protein domains in the human genome, we extend the principle of recurrence analysis by aggregating mutations in homologous positions across sets of paralogous genes. Protein domain analysis enhances the statistical power to detect cancer-relevant mutations and links mutations to the specific biological functions encoded in domains. We illustrate how the MutationAligner database and interactive web tool can be used to explore, visualize and analyze mutation hotspots in protein domains across genes and tumor types. We believe that MutationAligner will be an important resource for the cancer research community by providing detailed clues for the functional importance of particular muta...

• Type: Journal
• Year: 2016
• Where: NAR
• Authors: Nicholas Paul Gauthier, Ed Reznik, Jianjiong Gao, Selçuk Onur Sümer, Nikolaus Schultz, Chris Sander, Martin L. Miller
• Keywords: NAR 2016