Ontological visualization of protein-protein interactions

Background: Cellular processes require the interaction of many proteins across several cellular compartments. Determining the collective network of such interactions is an important aspect of understanding the role and regulation of individual proteins. The Gene Ontology (GO) is used by model organism databases and other bioinformatics resources to provide functional annotation of proteins. The annotation process provides a mechanism to document the binding of one protein with another. We have constructed protein interaction networks for mouse proteins utilizing the information encoded in the GO annotations. The work reported here presents a methodology for integrating and visualizing information on protein-protein interactions. Results: GO annotation at Mouse Genome Informatics (MGI) captures 1318 curated, documented interactions. These include 129 binary interactions and 125 interaction involving three or more gene products. Three networks involve over 30 partners, the largest invol...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Harold J. Drabkin, Christopher Hollenbeck, David P. Hill, Judith A. Blake
• Keywords: Annotation, BMCBI 2005, Cellular Compartments, Protein