— This paper describes a new power minimizing method by optimizing supply voltage control and minimizing leakage in active and standby modes, respectively. In the active mode, the control system determines the optimal trade-off between supply voltage and the forward body bias voltage to satisfy the performance requirement. In the standby mode, a new optimal body-bias technique in nanoscale CMOS technology is implemented to monitor subthreshold, gate tunneling, and bandto-band tunneling leakage current and reduce leakage current by optimal substrate bias voltage(forward of reverse biasing). The optimal body bias control system reduces the leakage current by up to 1000 times for ISCAS85 benchmark circuits designed using 32nm CMOS technology.