Ori-Finder: A web-based system for finding oriCs in unannotated bacterial genomes

Background: Chromosomal replication is the central event in the bacterial cell cycle. Identification of replication origins (oriCs) is necessary for almost all newly sequenced bacterial genomes. Given the increasing pace of genome sequencing, the current available software for predicting oriCs, however, still leaves much to be desired. Therefore, the increasing availability of genome sequences calls for improved software to identify oriCs in newly sequenced and unannotated bacterial genomes. Results: We have developed Ori-Finder, an online system for finding oriCs in bacterial genomes based on an integrated method comprising the analysis of base composition asymmetry using the Z-curve method, distribution of DnaA boxes, and the occurrence of genes frequently close to oriCs. The program can also deal with unannotated genome sequences by integrating the gene-finding

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Feng Gao, Chun-Ting Zhang
• Keywords: Bacterial Genomes, BMCBI 2008, Genome, Unannotated Bacterial Genomes