A Pivoting Algorithm for Metabolic Networks in the Presence of Thermodynamic Constraints

A linear programming algorithm is presented to constructively compute thermodynamically feasible fluxes and change in chemical potentials of reactions for a metabolic network. It is based on physical laws of mass conservation and the second law of thermodynamics that all chemical reactions should satisfy. As a demonstration, the algorithm has been applied to the core metabolic pathway of E. coli.

• Type: Conference
• Year: 2005
• Where: CSB
• Authors: R. Nigam, S. Liang
• Keywords: Bioinformatics, Core Metabolic Pathway, CSB 2005, Linear Programming Algorithm, Metabolic Network