Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors

Metabotropic glutamate receptors (mGluRs) are G protein coupled receptors that play important roles in synaptic plasticity and other neuro-physiological and pathological processes. Allosteric mGluR ligands are particularly promising drug targets because of their modulatory effects

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Naveena Yanamala, Kalyan C. Tirupula, Judith Klein-Seetharaman
• Keywords: BMCBI 2008, Inactive Conformations, Mglur, Negative Modulators