A Probabilistic Method to Identify Compensatory Substitutions for Pathogenic Mutations

real or abstract. It provides a widely applicable approach to the prediction of compensatory substitutions for CPDs, avoiding any reliance on rigid non-probabilistic criteria or structural data. The detection of compensatory substitutions that facilitate the substitution of otherwise pathogenic variants offers valuable insight into the molecular constraints imposed on adaptive evolution.

• Type: Conference
• Year: 2007
• Where: APBC
• Authors: B. C. Easton, A. V. Isaev, Gavin A. Huttley, Peter Maxwell
• Keywords: APBC 2007, Applicable Approach, Bioinformatics, Compensatory Substitutions, Rigid Non-probabilistic Criteria