Protein subcellular localization prediction for Gram-negative bacteria using amino acid subalphabets and a combination of multip

Background: Predicting the subcellular localization of proteins is important for determining the function of proteins. Previous works focused on predicting protein localization in Gram-negative bacteria obtained good results. However, these methods had relatively low accuracies for the localization of extracellular proteins. This paper studies ways to improve the accuracy for predicting extracellular localization in Gram-negative bacteria. Results: We have developed a system for predicting the subcellular localization of proteins for Gram-negative bacteria based on amino acid subalphabets and a combination of multiple support vector machines. The recall of the extracellular site and overall recall of our predictor reach 86.0% and 89.8%, respectively, in 5-fold cross-validation. To the best of our knowledge, these are the most accurate results for predicting subcellular localization in Gram-negative bacteria. Conclusion: Clustering 20 amino acids into a few groups by the proposed greed...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Jiren Wang, Wing-Kin Sung, Arun Krishnan, Kuo-Bin Li
• Keywords: BMCBI 2005, Gram-negative Bacteria, Protein, Subcellular Localization