PSORTdb - an expanded, auto-updated, user-friendly protein subcellular localization database for Bacteria and Archaea

The subcellular localization (SCL) of a microbial protein provides clues about its function, its suitability as a drug, vaccine or diagnostic target and aids experimental design. The first version of PSORTdb provided a valuable resource comprising a data set of proteins of known SCL (ePSORTdb) as well as pre-computed SCL predictions for proteomes derived from complete bacterial genomes (cPSORTdb). PSORTdb 2.0 (http://db.psort.org) extends user-friendly functionalities, significantly expands ePSORTdb and now contains precomputed SCL predictions for all prokaryotes— including Archaea and Bacteria with atypical cell wall/membrane structures. cPSORTdb uses the latest version of the SCL predictor PSORTb (version 3.0), with higher genome prediction coverage and functional improvements over PSORTb 2.0, which has been the most precise bacterial SCL predictor available. PSORTdb 2.0 is the first microbial protein SCL database reported to have an automatic updating mechanism to regularly gener...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Nancy Y. Yu, Matthew R. Laird, Cory Spencer, Fiona S. L. Brinkman
• Keywords: Bacterial Genomes, Functional Improvements, Microbial Protein, NAR 2011