Abstract: This paper targets the reactive autonomic system's self-monitoring of one of the most important nonfunctional properties, reliability. There are currently no adequate frameworks for tackling reliability in reactive and autonomic systems with self-monitoring functionality. The proposed in the paper reliability self-assessment of the Autonomic System Timed Reactive Model (AS-TRM) is based on the theory of Markov chains and is concerned with the uncertainty analysis of the AS-TRM as it evolves. An appropriate architecture for supporting reliability selfassessment is presented, along with a communication mechanism to implement the reactive and autonomic behavior. The reliability assessment is illustrated on a case study.