REPAIRtoire - a database of DNA repair pathways

REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii) pathways comprising individual processes and enzymatic reactions involved in the removal of damage, (iii) proteins participating in DNA repair and (iv) diseases correlated with mutations in genes encoding DNA repair proteins. REPAIRtoire provides also links to publications and external databases. REPAIRtoire contains information about eight main DNA damage checkpoint, repair and tolerance pathways: DNA damage signaling, direct reversal repair, base excision repair, nucleotide excision repair, mismatch repair, homologous recombination repair, nonhomologous end-joining and translesion synthesis. The pathway/protein dataset is currently limited to three model organisms: Escherichia coli, Saccharomyces cerevisiae and Homo sapiens. The DNA rep...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Kaja Milanowska, Joanna Krwawicz, Grzegorz Papaj, Jan Kosinski, Katarzyna Poleszak, Justyna Lesiak, Ewelina Osinska, Kristian Rother, Janusz M. Bujnicki
• Keywords: Dna Damage Checkpoint, DNA Repair Proteins, NAR 2011, Nucleotide Excision Repair