SCLD: a stem cell lineage database for the annotation of cell types and developmental lineages

Stem cell biology has experienced explosive growth over the past decade as researchers attempt to generate therapeutically relevant cell types in the laboratory. Recapitulation of endogenous developmental trajectories is a dominant paradigm in the design of directed differentiation protocols, and attempts to guide stem cell differentiation are often based explicitly on knowledge of in vivo development. Therefore, when designing protocols, stem cell biologists rely heavily upon information including (i) cell type-specific gene expression profiles, (ii) anatomical and developmental relationships between cells and tissues and (iii) signals important for progression from progenitors to target cell types. Here, we present the Stem Cell Lineage Database (SCLD) (http://scld.mcb.uconn .edu) that aims to unify this information into a single resource where users can easily store and access information about cell type gene expression, cell lineage maps and stem cell differentiation protocols for...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Edward Hemphill, Asav P. Dharia, Chih Lee, Caroline M. Jakuba, Jason D. Gibson, Frederick W. Kolling IV, Craig E. Nelson
• Keywords: Gene Expression Profiles, NAR 2011, Specific Gene Expression, Stem Cell Biology