— In this paper we present a cross-domain application for ambient and health monitoring. The system architecture is intended to be openly extensible in order to fulfil unanticipated needs. Our implementation addresses diverse groups, from those requiring heart related monitoring, which could be dependent on the environmental conditions, to those who need to maximize environmental comfort under specified energy consumption constraints. In this application the ambient information is used to enrich the biomedical data and provide a more complete picture to the information consumers, such as doctors and building superintendents. The cross-domain nature of the scenario requires data interoperability, which is ensured by a shared Smart Space. The Smart Space represents the information in Resource Description Framework and its semantics are ontology driven. A simple ontology for the addressed information domain is also presented. The Smart Space platform is provided by the JTI Artemis SOFIA...