Stability analysis of mixtures of mutagenetic trees

Background: Mixture models of mutagenetic trees are evolutionary models that capture several pathways of ordered accumulation of genetic events observed in different subsets of patients. They were used to model HIV progression by accumulation of resistance mutations in the viral genome under drug pressure and cancer progression by accumulation of chromosomal aberrations in tumor cells. From the mixture models a genetic progression score (GPS) can be derived that estimates the genetic status of single patients according to the corresponding progression along the tree models. GPS values were shown to have predictive power for estimating drug resistance in HIV or the survival time in cancer. Still, the reliability of the exact values of such complex markers derived from graphical models can be questioned. Results: In a simulation study, we analyzed various aspects of the stability of estimated mutagenetic trees mixture models. It turned out that the induced probabilistic distributions an...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Jasmina Bogojeska, Thomas Lengauer, Jörg Rahnenführer
• Keywords: BMCBI 2008, Genetic Progression Scores, Mutagenetic Trees, Single Patients