Sciweavers

BMCBI
2008

Standardized high-throughput evaluation of cell-based compound screens

14 years 17 days ago
Standardized high-throughput evaluation of cell-based compound screens
Background: High-throughput screening of pharmaceutical compound activity in tissue culture experiments requires time-consuming repeated analysis of the large amounts of data generated. Automation of the evaluation procedure and assessment of measurement accuracy can save time and improve the comparability of results. Results: We present a tool for simultaneous evaluation of an arbitrary number of compound screens including a standardized statistical validation. It is provided as a novel R package with a Tcl/ Tk-based GUI for convenient use in the lab and runs on usual platforms like Linux, Windows and Mac OS. In a compound screen of lung cancer cells, the tool was successfully and efficiently applied for data analysis. Conclusion: The package provides an efficient and intuitive platform for automatic evaluation of compound screens, improving the performance and standardization of data analysis. Background Cell-based screening of the cytotoxic activity of chemical compounds in cancer ...
Peter Frommolt, Roman K. Thomas
Added 08 Dec 2010
Updated 08 Dec 2010
Type Journal
Year 2008
Where BMCBI
Authors Peter Frommolt, Roman K. Thomas
Comments (0)