A Sublinear-Time Randomized Approximation Scheme for the Robinson-Foulds Metric

The Robinson-Foulds (RF) metric is the measure most widely used in comparing phylogenetic trees; it can be computed in linear time using Day's algorithm. When faced with the need to compare large numbers of large trees, however, even linear time becomes prohibitive. We present a randomized approximation scheme that provides, with high probability, a (1 + ) approximation of the true RF metric for all pairs of trees in a given collection. Our approach is to use a sublinear-space embedding of the trees, combined with an application of the Johnson-Lindenstrauss lemma to approximate vector norms very rapidly. We discuss the consequences of various parameter choices (in the embedding and in the approximation requirements). We also implemented our algorithm as a Java class that can easily be combined with popular packages such as Mesquite; in consequence, we present experimental results illustrating the precision and running-time tradeoffs as well as demonstrating the speed of our approa...

• Type: Conference
• Year: 2006
• Where: RECOMB
• Authors: Nicholas D. Pattengale, Bernard M. E. Moret
• Keywords: Computational Biology, Linear Time, Randomized Approximation Scheme, RECOMB 2006, Various Parameter Choices