— This paper evaluates various instruction- and data-cache organizations in terms of performance, power, energy and area on a suitably selected biomedical benchmark suite. The benchmark suite consists of compression, encryption and data-integrity algorithms as well as real implant applications, all executed on biomedical input datasets. Results are used to drive the (micro)architectural design of a novel microprocessor targeting microelectronic implants. Our profiling study has revealed a L1 instruction-cache of 8 KB size (when relaxed area constraints are imposed) and a L1 data-cache of 4 KB size, both structured as 2-way associative caches, as optimal organizations for the envisioned implant processor.