This paper presents a systematic and optimal design of hybrid cascode compensation method which is used in fully differential two-stage CMOS operational transconductance amplifiers (OTAs). The closed loop analysis results are given to obtain a design procedure. A simple design procedure for the minimum settling time of the hybrid cascode compensation technique for a twostage class A/AB amplifier is proposed. Optimal design issues of power dissipation are considered to achieve the lowest power consumption for the required settling time. Finally, a design example is presented to show both the usefulness of the hybrid cascode compensation and the proposed design procedure. The proposed design technique can help circuit designers as well as it can be used in computer aided circuit design tools.