Graphs are widely used to model complicated data semantics in many applications. In this paper, we aim to develop efficient techniques to retrieve graphs, containing a given query graph, from a large set of graphs. Considering the problem of testing subgraph isomorphism is generally NP-hard, most of the existing techniques are based on the framework of filtering-and-verification to reduce the precise computation costs; consequently various novel feature-based indexes have been developed. While the existing techniques work well for small query graphs, the verification phase becomes a bottleneck when the query graph size increases. Motivated by this, in the paper we firstly propose a novel and efficient algorithm for testing subgraph isomorphism, QuickSI. Secondly, we develop a new feature-based index technique to accommodate QuickSI in the filtering phase. Our extensive experiments on real and synthetic data demonstrate the efficiency and scalability of the proposed techniques, which s...