TcoF-DB: dragon database for human transcription co-factors and transcription factor interacting proteins

The initiation and regulation of transcription in eukaryotes is complex and involves a large number of transcription factors (TFs), which are known to bind to the regulatory regions of eukaryotic DNA. Apart from TF–DNA binding, protein–protein interaction involving TFs is an essential component of the machinery facilitating transcriptional regulation. Proteins that interact with TFs in the context of transcription regulation but do not bind to the DNA themselves, we consider transcription co-factors (TcoFs). The influence of TcoFs on transcriptional regulation and initiation, although indirect, has been shown to be significant with the functionality of TFs strongly influenced by the presence of TcoFs. While the role of TFs and their interaction with regulatory DNA regions has been well-studied, the association between TFs and TcoFs has so far been given less attention. Here, we present a resource that is comprised of a collection of human TFs and the TcoFs with which they interact...

• Type: Journal
• Year: 2011
• Where: NAR
• Authors: Ulf Schaefer, Sebastian Schmeier, Vladimir B. Bajic
• Keywords: Dna Binding Protein, NAR 2011, Transcription Co, Transcription In Eukaryotes