This panel will discuss possible exciting and motivating Grand Challenge problems for Data Mining, focusing on bioinformatics, multimedia mining, link mining, text mining, and web mining. Categories and Subject Descriptors H.2.8 [Database Applications]: Data mining General Terms Measurement, Performance, Experimentation. Keywords Data mining, bioinformatics, multimedia mining, image mining, video mining, link mining, text mining, web mining, grand challenge, X-prize.