Validating Gene Clusterings by Selecting Informative Gene Ontology Terms with Mutual Information

Abstract. We propose a method for global validation of gene clusterings. The method selects a set of informative and non-redundant GO terms through an exploration of the Gene Ontology structure guided by mutual information. Our approach yields a global assessment of the clustering quality, and a higher level interpretation for the clusters, as it relates GO terms with specific clusters. We show that in two gene expression data sets our method offers an improvement over previous approaches. Key words: cluster validation, external index, gene ontology, mutual information

• Type: Conference
• Year: 2007
• Where: WOB
• Authors: Ivan G. Costa, Marcílio Carlos Pereira de Souto, Alexander Schliep
• Keywords: Gene Ontology, Gene Ontology Structure, GO Terms, WOB 2007, WOB 2008