Very Important Pool (VIP) genes - an application for microarray-based molecular signatures

Background: Advances in DNA microarray technology portend that molecular signatures from which microarray will eventually be used in clinical environments and personalized medicine. Derivation of biomarkers is a large step beyond hypothesis generation and imposes considerably more stringency for accuracy in identifying informative gene subsets to differentiate phenotypes. The inherent nature of microarray data, with fewer samples and replicates compared to the large number of genes, requires identifying informative genes prior to classifier construction. However, improving the ability to identify differentiating genes remains a challenge in bioinformatics. Results: A new hybrid gene selection approach was investigated and tested with nine publicly available microarray datasets. The new method identifies a Very Important Pool (VIP) of genes from the broad patterns of gene expression data. The method uses a bagging sampling principle, where the re-sampled arrays are used to identify the...

• Type: Journal
• Year: 2008
• Where: BMCBI
• Authors: Zhenqiang Su, Huixiao Hong, Hong Fang, Leming M. Shi, Roger Perkins, Weida Tong
• Keywords: BMCBI 2008, Gene Selection Approach, Informative Genes, Vip Gene