Visualization and analysis of microarray and gene ontology data with treemaps

Background: The increasing complexity of genomic data presents several challenges for biologists. Limited computer monitor views of data complexity and the dynamic nature of data in the midst of discovery increase the challenge of integrating experimental results with information resources. The use of Gene Ontology enables researchers to summarize results of quantitative analyses in this framework, but the limitations of typical browser presentation restrict data access. Results: Here we describe extensions to the treemap design to visualize and query genome data. Treemaps are a space-filling visualization technique for hierarchical structures that show attributes of leaf nodes by size and color-coding. Treemaps enable users to rapidly compare sizes of nodes and sub-trees, and we use Gene Ontology categories, levels of RNA, and other quantitative attributes of DNA microarray experiments as examples. Our implementation of treemaps, Treemap 4.0, allows user-defined filtering to focus on...

• Type: Journal
• Year: 2004
• Where: BMCBI
• Authors: Eric H. Baehrecke, Niem Dang, Ketan Babaria, Ben Shneiderman
• Keywords: BMCBI 2004, DNA Microarray, Gene Ontology, Treemap