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BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2010
153views more  BMCBI 2010»
13 years 7 months ago
Starr: Simple Tiling ARRay analysis of Affymetrix ChIP-chip data
Background: Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is an assay used for investigating DNA-protein-binding or post-translational chromatin/histone ...
Benedikt Zacher, Pei Fen Kuan, Achim Tresch
BMCBI
2010
173views more  BMCBI 2010»
13 years 7 months ago
The Yeast Resource Center Public Image Repository: A large database of fluorescence microscopy images
Background: There is increasing interest in the development of computational methods to analyze fluorescent microscopy images and enable automated large-scale analysis of the subc...
Michael Riffle, Trisha N. Davis
BIOSYSTEMS
2008
107views more  BIOSYSTEMS 2008»
13 years 7 months ago
The linearity of emergent spectro-temporal receptive fields in a model of auditory cortex
The responses of cortical neurons are often characterized by measuring their spectro-temporal receptive fields (strfs). The strf of a cell can be thought of as a representation of...
Martin Coath, Emili Balaguer-Ballester, Sue L. Den...
BMCBI
2010
132views more  BMCBI 2010»
13 years 7 months ago
Next generation tools for genomic data generation, distribution, and visualization
Background: With the rapidly falling cost and availability of high throughput sequencing and microarray technologies, the bottleneck for effectively using genomic analysis in the ...
David A. Nix, Tonya L. Di Sera, Brian K. Dalley, B...