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» A Comparison of Noise Handling Techniques
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HICSS
2003
IEEE
220views Biometrics» more  HICSS 2003»
14 years 27 days ago
Applications of Hidden Markov Models to Detecting Multi-Stage Network Attacks
This paper describes a novel approach using Hidden Markov Models (HMM) to detect complex Internet attacks. These attacks consist of several steps that may occur over an extended pe...
Dirk Ourston, Sara Matzner, William Stump, Bryan H...
CSB
2004
IEEE
112views Bioinformatics» more  CSB 2004»
13 years 11 months ago
Reasoning about Molecular Similarity and Properties
Ascertaining the similarity amongst molecules is a fundamental problem in biology and drug discovery. Since similar molecules tend to have similar biological properties, the notio...
Rahul Singh
BMCBI
2008
92views more  BMCBI 2008»
13 years 7 months ago
A semiparametric modeling framework for potential biomarker discovery and the development of metabonomic profiles
Background: The discovery of biomarkers is an important step towards the development of criteria for early diagnosis of disease status. Recently electrospray ionization (ESI) and ...
Samiran Ghosh, David F. Grant, Dipak K. Dey, Denni...
BMCBI
2006
92views more  BMCBI 2006»
13 years 7 months ago
Similarity-based gene detection: using COGs to find evolutionarily-conserved ORFs
Background: Experimental verification of gene products has not kept pace with the rapid growth of microbial sequence information. However, existing annotations of gene locations c...
Bradford C. Powell, Clyde A. Hutchison III
BMCBI
2005
152views more  BMCBI 2005»
13 years 7 months ago
Improved profile HMM performance by assessment of critical algorithmic features in SAM and HMMER
Background: Profile hidden Markov model (HMM) techniques are among the most powerful methods for protein homology detection. Yet, the critical features for successful modelling ar...
Markus Wistrand, Erik L. L. Sonnhammer